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Here are some recent publications from the lab and our collaborators:

 

  • Kornberg JR, Brown JL, Sadovnick AD, Remick RA, Keck Jr PE, McElroy SL, Rapaport MH, Thompson P, Kaul JB, Vrabel CM, Schommer SC, Wilson T, Pizzuco D, Jameson S, Schibuk L, Kelsoe JR. Evaluating the parent-of-origin effect in bipolar affective disorder.  J Affective Disorders 59(3):183-192, 2000.

  • Shilling PD, Kelsoe JR, Kuczenski R, Segal DS. Differential regional zif268 messenger RNA expression in an escalating dose/binge model of amphetamine-induced psychosis. Neuroscience 96:83-90, 2000.

  • Shilling PD, Feifel D, Kelsoe JR. Amphetamine-induced zif268 mRNA expression in the medial posterior nucleus accumbens in Cholecystokinin-A receptor mutant rats. Neuroscience Letters 281:17-20, 2000.

  • Niculescu AB, Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR.  Identifying a series of candidate genes for mania and psychosis:  a convergent functional genomics approach.    Physiological Genomics 4:83-91, 2000.

  •  Mendlowicz MV, Girardin J-L, Gillin JC, Akiskal HS, Furlanetto LM, Rapaport MH, Kelsoe JR. Sociodemographic Predictors of Temperament and Character. J Psychiatric Res 34(3):221-226, 2000.

  • Greenwood TA, Alexander M, Keck PE, McElroy S, Sadovnick AD, Remick RA, Kelsoe JR. Evidence for Linkage Disequilibrium between the Dopamine Transporter and Bipolar Disorder. Am J Med Genet (Neuropsychiatric Genetics) 105:145-151, 2001.

  • Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown JL, Masser D, Ungerleider S, Rapaport MH, Wishart WL, Luebbert H.  A genome survey indicates a susceptibility locus for bipolar disorder on chromosome 22. Proceedings of the National Academy of Sciences 98:585-590, 2001.

  • Girardin J-L, Mendlowicz MV, Gillin JC, Rapaport MH, Kelsoe JR, Zizi F, Landolt H-P, von Gizycki H.  Sleep estimation from wrist activity in patients with major depression.  Physiol Behav 70(1-2):49-53, 2000.

  •  Niculescu AB, Kelsoe JR.  Convergent functional genomics:  application to bipolar disorder.  Annals of Medicine 33:263-271, 2001.

  • Greenwood TA, Alexander M, Keck PE, McElroy S, Sadovnick AD, Remick RA, Shaw SH, Kelsoe JR.  Segmental Linkage Disequilibrium within the Dopamine Transporter Gene.  Molecular Psychiatry 7:165-173, 2002.

  •  Shilling PD, Kelsoe JR.  Functional genomics approaches to understanding brain disorders.  Pharmacogenomics 3(1):31-47, 2002.

  • Gershon ES, Kelsoe JR, Kendler KS, Watson JD.  A scientific opportunity:  It’s time to search for susceptibility genes for major mental illnesses.  Editorial, Science 294:957, 2001.

  • Johansson C, Jansson M, Linner L, Yuan Q-P, Pedersen NL, Blackwood D, Barden N, Kelsoe J, Schalling M.  Genetics of affective disorders.   European Neuropsychopharmacology 11:385-394, 2001.

  • Kelsoe JR.  Arguments for the genetic basis of the bipolar spectrum. Journal of Affective Disorders 73:183-197, 2003.

  • Liang SG, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Kelsoe JR.  A linkage disequilibrium study of bipolar disorder and microsatellite markers on 22q13.  Psychiatric Genetics 12: 231-235, 2002.

  • Evans L, Golshan S, Kelsoe J, Rapaport M, Resovsky K, Sutton L, Gillin JC.  Effects of rapid tryptophan depletion on sleep electroencephalogram and mood in subjects with partially remitted depression on bupropion.  Neuropsychopharmacology 27: 1016-1026, 2002.

  • Shaw SH, Mroczkowski-Parker Z, Shekhtman T, Alexander M, Remick RA, Sadovnick AD, McElroy SL, Keck PE, Kelsoe JR.  Linkage of a bipolar disorder susceptibility locus to human chromosome 13q32 in a new pedigree series. Molecular Psychiatry 8: 558-564, 2003.

  • Barrett TB, Hauger RL, Kennedy JL, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Alexander M, Shaw SH, Kelsoe JR.  Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 is associated with bipolar disorder.  Molecular Psychiatry 8: 546-557, 2003. (supplemental data for this paper is posted here)

  • Landolt H-P, Kelsoe JR, Rapaport MH, Gillin JC.  Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep.  J Sleep Res 12:13-18, 2003.

  • Kelsoe JR.  The blooming of psychiatric genetics.  Book review of “Psychiatric Genetics and Genomics” The Lancet 361:1233, 2003.

  • Hawi Z, Lowe N, Kirley A, Gruenhage F, Nöthen M, Greenwood T, Kelsoe J, Fitzgerald M, Gill M.  Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci.  Molecular Psychiatry 8: 299-308, 2003.

  • Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI Jr, Craddock N, DePaulo JR, Baron M, Gershon ES, Ekholm J, Cichon S, Turecki G, Claes S, Kelsoe JR, Schofield PR, Badenhop RF, Morissette J, Coon H, Blackwood D, McInnes LA, Foroud T, Edenberg HJ, Reich T, Rice JP, Goate A, McInnis MG, McMahon FJ, Badner JA, Goldin LR, Bennett P, Willour VL, Zandi PP, Liu J, Gilliam C, Juo S-H, Berrettini WH, Yoshikawa T, Peltonen L, Lönnqvist J, Nöthen MM, Schumacher J, Windemuth C, Rietschel M, Propping P, Maier W, Alda M, Grof P, Rouleau GA, Del-Favero J, Van Broeckhoven C, Mendlewicz J, Adolfsson R, Spence MA, Luebbert H, Adams LJ, Donald JA, Mitchell PB, Barden N, Shink E, Byerley W, Muir W, Visscher PM, Macgregor S, Gurling H, Kalsi G, McQuillan A,  Escamilla MA, Reus VI, Leon P, Freimer NB, Ewald H, Kruse TA, Mors O, Radhakrishna U, Blouin J-L, Antonarakis SE, Akarsu N.   Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder.  Am J Hum Genet 73:49-62, 2003.

  • Dick DM, Foroud T, Flury L, Bowman ES, Miller MJ, Rau NL, Moe PR, Samavedy N,  El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Hahn R, Widmark C, McKinney R, Sutton L, Ballas C, Grice D, Berrettini W, Byerley W, Coryell W, DePaulo R, Gershon ES, Kelsoe JR, McMahon FJ, McInnis M, Murphy DL, Reich T, Scheftner W, Nurnberger JI, Jr.  Genomewide Linkage Analyses of Bipolar Disorder: A New Sample of 250 Pedigrees from the National Institute of Mental Health Genetics Initiative.  Am J Hum Genet 73:107-114, 2003.

  • Greenwood TA, Kelsoe JR. Promoter and intronic variants affect the transcriptional regulation of the human dopamine transporter gene. Genomics, 82: 511-519, 2003.

  • Schuckit MA, Kelsoe JR, Braff DL, Wilhelmsen KC.  Some possible genetic parallels across alcoholism, bipolar disorder and schizophrenia.  Editorial.  Journal of Studies on Alcohol 64:157-159, 2003.

  • Kelsoe JR.  Update on the Search for Genes for Bipolar Disorder.  Current Psychosis and Therapeutics Reports 1:62-66, 2003.

  • Schulze TG, Buervenich S, Badner JA, Steele CJM, Detera-Wadleigh SD, Dick D, Foroud T, Cox NJ, MacKinnon DA, Potash JB, Berrettini W, Byerley W, Coryell W, DePaulo JR Jr, Gershon ES, Kelsoe JR, McInnis MG, Murphy DLL, Reich T, Scheftner W, Nurnberger JI Jr,  McMahon FJ.  Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the NIMH Genetics Initiative pedigrees.  Biol Psych, 56:18-23, 2004.

  • Evans L, Akiskal HS, Keck PE, McElroy SL, Sadovnick AD, Remick RA, Kelsoe JR.  Familiality of temperament in bipolar disorder: Support for a genetic spectrum. J Affective Disorders, in press.

  • Mendlowicz MV, Akiskal HS, Kelsoe JR, Rapaport MH, Jean-Louis G, Gillin JC.  Temperament in the clinical differentiation of depressed bipolar and unipolar major depressive patients.  J Affective Disorders, in press.

  • Cichon S, Buervenich S, Kirov G, Akula N, Dimitrova A,  Green E, Schumacher J, Klopp N, Becker T, Ohlraun S, Schulze TG, Tullius M, Gross MM, Jones L, Krastev S, Nikolov I, Hamshere M, Jones I, Czerski PM, Leszcynska-Rodziewicz A, Kapelski P, Van Den Bogaert A, Illig T, Hauser J, Maier W, Berrettini W, Byerley W, Coryell W, JR, Gershon ES, Kelsoe JR, McInnis MG, Murphy DL, Nurnberger Jr JI, Reich T, Scheftner W, O’Donovan MC, Propping P, Owen MJ, Rietschel M, Nöthen MM, McMahon FJ, Craddock N.   Lack of support for a genetic association of the XBP1 promoter polymorphism (-116C®G) in family-based and case-control samples including 1,767 bipolar I probands of European origin.  Nature Genetics, in press.

  • Nievergelt CM, Kripke DF, Remick RA, Sadovnick AD, McElroy SL, Keck PR, Kelsoe JR.  Examination of the clock gene Cryptochrome 1 in bipolar disorder: mutational analysis and absence of evidence for linkage or association.  Psychiatric Genetics, in press.

  • Kimmel RJ, Kovacs I, Vrabel C, Wood B, Schalling M, Kelsoe JR.  Cosegregation of bipolar disorder and autosomal-dominant medullary cystic kidney disease in a large family.  Am J Psychiatry, in press.